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Nucleotide deletions in dengue virus 3’ untranslated region compromises protein translation of live attenuated dengue vaccine strains
Kiven Kumar, Justin SG Ooi, Charlene HM Leong, Hwee Cheng Tan, Wy Ching Ng, Kuan Rong Chan, Esteban Finol, Eng Eong Ooi. NPJ Vaccines.
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Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial
Punitha Sivanandam, Ayesa Syenina, Yvonne FZ Chan, Dorothy HL Ng, Esther S Gan, Jia Xin Yee, Christine YL Tham, Hwee Cheng Tan, Eugenia Z Ong, Eng Eong Ooi, Shirin Kalimuddin. Commun Med. PubMed ID: 42177367
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Influence of obesity on susceptibility to systemic symptoms and host responses to orthoflaviviral infection: a prospective observational study using yellow fever vaccine to simulate acute infection
Ayesa Syenina, Christine Y.L. Tham, Danny J.H. Tng, Valerie S.Y. Chew, Jia Xin Yee, Yan Shan Leong, Noor Zayanah Hamis, Hwee Cheng Tan, Han Yi Joon, Jing Ti Chan, Yuchen Yang, Yin Bun Cheung, Eugenia Z. Ong, Jenny G. Low, Eng Eong Ooi. eBioMedicine. PubMed ID: 42107906
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Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans
Justin S.G. Ooi, Noor Zayanah Hamis, Hwee Cheng Tan, Jia Xin Yee, Valerie S.Y. Chew, Joey Ming Er Lim, Eugenia Z. Ong, Kuan Rong Chan, Laura Rivino, Jenny G. Low, Eng Eong Ooi, Shirin Kalimuddin. Vaccine. PubMed ID: 41880822
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Reduced dengue virus pre-membrane protein-HMGB1 interaction activates host cell transcription to attenuate infection
Siriphanitchakorn T, Ooi JSG, Ng WC, Tan HC, Zhang SL, Ng DHL, Yap X, Yee JX, Zheng Q, Tan YT, Ong EZ, Chan KR, Choy MM, Ooi EE. NPJ Vaccines. PubMed ID: 41702930
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Dengue virus infection reprograms baseline innate immune gene expression
Ong EZ, Yee JX, Koh CW, Ooi JS, Tham CYL, Chan KR, Kareko BW, Lyski ZL, Tricou V, Dean H, Braun R, Kalimuddin S, Low JG, Messer WB, Sharma M, Ooi EE. Med. PubMed ID: 40925380
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Vaccine-induced T cell responses control Orthoflavivirus challenge infection without neutralizing antibodies in humans
Kalimuddin S, Tham CYL, Chan YFZ, Hang SK, Kunasegaran K, Chia A, Chan CYY, Ng DHL, Sim JXY, Tan HC, Syenina A, Ngoh AQ, Hamis NZ, Chew V, Leong YS, Yee JX, Low JG, Chan KR, Ong EZ, Bertoletti A, Ooi EE. Nat Microbiol. PubMed ID: 39794472
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ASO1-adjuvanted vaccine alters baseline correlates of T cell response to varicella zoster virus in older adults
Chan CCY, Ooi JSG, Koh CWT, Ong EZ, Tham CYL, Yee JX, Chew VSY, Cheung YB, Ooi EE, Low JG, Chan KR. Vaccine. PubMed ID: 40592255
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Cancer type and gene signatures associated with breakthrough infections following COVID-19 mRNA vaccination
Zhong Y, Li J, Lee ARYB, Tan JYJ, Tay CJX, Koh CW, Seow EYT, Yap WC, Wong SY, Yau CE, Low CE, Tan KB, Young BE, Su Y, Devasia AG, Dharuman P, Lezhava A, Pandey R, Govindaraju PS, Yee S, Weng R, Khoo C, Tan SSY, Lee M, Lim J, Chan E, Ho CL,…
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