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Nucleotide deletions in dengue virus 3’ untranslated region compromises protein translation of live attenuated dengue vaccine strains
Kiven Kumar, Justin SG Ooi, Charlene HM Leong, Hwee Cheng Tan, Wy Ching Ng, Kuan Rong Chan, Esteban Finol, Eng Eong Ooi. NPJ Vaccines.
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Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial
Punitha Sivanandam, Ayesa Syenina, Yvonne FZ Chan, Dorothy HL Ng, Esther S Gan, Jia Xin Yee, Christine YL Tham, Hwee Cheng Tan, Eugenia Z Ong, Eng Eong Ooi, Shirin Kalimuddin. Commun Med. PubMed ID: 42177367
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Influence of obesity on susceptibility to systemic symptoms and host responses to orthoflaviviral infection: a prospective observational study using yellow fever vaccine to simulate acute infection
Ayesa Syenina, Christine Y.L. Tham, Danny J.H. Tng, Valerie S.Y. Chew, Jia Xin Yee, Yan Shan Leong, Noor Zayanah Hamis, Hwee Cheng Tan, Han Yi Joon, Jing Ti Chan, Yuchen Yang, Yin Bun Cheung, Eugenia Z. Ong, Jenny G. Low, Eng Eong Ooi. eBioMedicine. PubMed ID: 42107906
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Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans
Justin S.G. Ooi, Noor Zayanah Hamis, Hwee Cheng Tan, Jia Xin Yee, Valerie S.Y. Chew, Joey Ming Er Lim, Eugenia Z. Ong, Kuan Rong Chan, Laura Rivino, Jenny G. Low, Eng Eong Ooi, Shirin Kalimuddin. Vaccine. PubMed ID: 41880822
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TMEM41B and VMP1 modulate cellular lipid energy metabolism for facilitating dengue virus infection
Yousefi M, Lee WS, Yan B, Cui L, Yong CL, Yap X, Tay KSL, Qiao W, Tan D, Nurazmi NI, Linster M, Smith GJD, Lee YH, Carette JE, Ooi EE, Chan KR*, Ooi YS. PLoS Pathog. PubMed ID: 35939522
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Temporal dynamics of the host molecular responses underlying severe COVID-19 progression and disease resolution
Ong EZ, Kalimuddin S, Chia WC, Ooi SH, Koh CW, Tan HC, Zhang SL, Low JG, Ooi EE, Chan KR. EBioMedicine. PubMed ID: 33691247
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A Dynamic Immune Response Shapes COVID-19 Progression
Ong EZ, Chan YFZ, Leong WY, Lee NMY, Kalimuddin S, Haja Mohideen SM, Chan KS, Tan AT, Bertoletti A, Ooi EE, Low JGH. Cell Host Microbe. PubMed ID: 32359396
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Antibody-dependent dengue virus entry modulates cell intrinsic responses for enhanced infection
Chan CYY, John JZH, Gan ES, Ong EZ, Zhang SL, Tan HC, Chai X, Ghosh S, Ooi EE, Chan KR. mSphere. PubMed ID: 31533998
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Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live attenuated yellow fever infection
Chan KR, Gan ES, Chan CY, Liang C, Low JZ, Zhang SL, Ong EZ, Bhatta A, Wijaya L, Lee YH, Low JG, Ooi EEE. Nat Med. PubMed ID: 31308506