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Nucleotide deletions in dengue virus 3’ untranslated region compromises protein translation of live attenuated dengue vaccine strains
Kiven Kumar, Justin SG Ooi, Charlene HM Leong, Hwee Cheng Tan, Wy Ching Ng, Kuan Rong Chan, Esteban Finol, Eng Eong Ooi. NPJ Vaccines.
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Reduced dengue virus pre-membrane protein-HMGB1 interaction activates host cell transcription to attenuate infection
Siriphanitchakorn T, Ooi JSG, Ng WC, Tan HC, Zhang SL, Ng DHL, Yap X, Yee JX, Zheng Q, Tan YT, Ong EZ, Chan KR, Choy MM, Ooi EE. NPJ Vaccines. PubMed ID: 41702930
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IgG, IgM and nonstructural protein 1 response profiles after receipt of tetravalent dengue vaccine TAK-003 in a phase 2 randomized controlled trial
Low JG, Oh HM, Leo YS, Kalimuddin S, Wijaya L, Pang J, Lee TH, Moss KJ, Brose M, Tricou V. Am J Trop Med Hyg. PubMed ID: 38806045
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A natural human cell-adapted dengue type 3 virus strain
Ng WC, Lin LZ, Siriphanitchakorn T, Jiang MKX, Tan HC, Ooi EE. Microbiology Spectrum. PubMed ID: 38847546
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A prM Mutation that attenuates dengue virus replication in human cells enhances midgut infection in mosquitoes
Choi ANX, Siriphanitchakorn T, Choy MM, Ooi JSG, Manuel M, Tan HC, Lin LZ, Yap X, Gubler DJ, Ooi EE. Sci Transl Med. PubMed ID: 39083584
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A fast-growing dengue virus mutant reveals a dual role of STING in response to infection
Ng WC, Kwek SS, Sun B, Yousefi M, One EZ, Tan HC, Puschnik AS, Chan KR, Ooi YS, Ooi EE. Open Biology. PubMed ID: 36514984
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A non-structural 1 protein G53D substituition attenuates a clinically tested live dengue vaccine
Choy MC, Ng DHL, Siriphanitchakorn T, Ng WC, Sundstrom KB, Tan HC, Zhang ZL, Chan KWK, Manuel M, Kini RM, Chan KR, Vasudevan SG, Ooi EE. Cell Reports. PubMed ID: 32402284
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A systemic approach to the development of a safe live attenuated Zika vaccine. Nature Communications
Kwek SS, Watanabe S, Chan KR, Ong EZ, Tan HC, Ng WC, Nguyen MTX, Gan ES, Zhang SL, Chan KWK, Tan JH, Sessions OM, Manuel M, Pompom J, Chua C, Hazirah S, Tryggvason K, Vasudevan SG, Ooi EE. Nature Communications. PubMed ID: 29531213